Avaliação de Mg, Al HDL como carreador de Sb(V), a partir de antimoniato de meglumina, visando uma alternativa para a quimioterapia da Leishmaniose

Abstract

As the main leishmaniasis control measure in all its forms, the World Health Organization (WHO) recommends the use of chemotherapy and, despite significant limitations accompanying antimony, as high incidence of toxic effects, the need for a long period of treatment and the route of administration used (parenteral), these remain the drugs of choice. The objective is therefore to investigate the preparation of nanostructured binary systems as an alternative in the treatment of leishmaniasis, through the use of anionic clays and layered double hydroxides (LDHs) as lamellar carriers pentavalent antimonial drugs. The choice of these carrier was made according to the chemical structure of the drugs, which could, through electrostatic interactions, a promising result in release control system in the form of powder. To this end, it was synthesized Mg, Al LDH precursor and meglumine antimoniate (MA), both had their training confirmed by characterization techniques. As clay and drug are soluble/ dispersible in water, we investigated the preparation of the solution via system (S-E1, S-E2 and S-E3) or co-precipitation (S-CP); in the first case as variables studied were the ratio m/m and temperature. Also, for comparative purposes, it was prepared physical mixture (PM) precursors. The TGA technique showed that the products via solution (S-E1 and S-E2) are not formed, however, through characterization techniques such as TGA, EDX, XRD, FTIR, SEM, it was confirmed to obtain the product S-E3 of the adsorbate type. ICP OES allowed the quantification of antimony in the product is 15.38%. The same techniques also support the formation of product II as the interleaved type, and quantified 9.17% antimony. Thus were obtained two different binary systems containing antimony associated to HDL and semi-metal, for speciation assays is presented largely in both the pentavalent state. Given the above, it is concluded that the formation of system LDH-Sb(V) from MA, can be viable and that nanotechnology has proven to be an ally in the search for alternatives to the limited chemotherapy of leishmaniasis.