Estudo da viabilidade de uma nova alternativa de tratamento tópico das lesões do colo uterino

Abstract

Cervical cancer is the fourth most common cancer in women, being the fourth leading cause of cancer death in Brazil. As cervical lesions produce a more common form of cervical cancer, in addition to being a gateway to various diseases. Currently, the form of early detection and treatment of cancerous lesions and pre-cancer includes a sequence of actions recommended by the Ministry of Health, which conducts clinical and surgical examinations, however, excludes the administration of drugs. In this context, the present study aimed to assess the feasibility of incorporating technology as a new alternative for treating topics on cervical lesions in primary health care, as well as developing new tools to learn or know among health professionals from the perspective of therapeutic and strategic solutions for lesions. This is a randomized, double-blind, controlled clinical trial with a prospective design. During the realization of this study, 158 women were attended, of which 61 patients were included in the study according to the inclusion requirements of phase I (ointment safety assessment), of these, 18 abandoned a survey. Thus, 43 women participated in the study who were included in the final analysis of the results, divided between groups A, which consisted of women using the ointment without silver nanoparticles (n=23) and B comprised a group of women who used the ointment with silver nanoparticles (n=20). When comparing the use of the ointment before and after use, we did not identify significant differences (p>0.05) in relation to the IVA test (p=0.157), and for the Schiller test (p=0.157). The present study indicates that Stryphnodendron adstringens (barbatimão) ointment is safe and tolerable for gynecological use. Regarding the product's effectiveness in cervical lesions, it is possible to reduce the number of lesions that have evolved to more severe forms and even cancer, reducing the number of lesions that have evolved to phase II, preventing a woman from being subjected to more advanced procedures. invasive and painful, in addition to the possibility of reducing public spending, and promoting the scientific development of young researchers.