Mensuração de biomarcadores na identificação precoce de lesão renal em cadelas com piometra

Abstract

Pyometra is a common reproductive disease in intact female dogs and consists of uterine infection, frequently affected by Escherichia coli (E. coli) bacteria, with formation of purulent secretion, which can generate glomerular and / or tubular dysfunctions, or both, even after performing the hysterectomy (OH) ovary. Proteinuria is identified in approximately half of bitches with pyometra, which is generally mild and often transient. However, approximately 8% of dogs with pyometra by E. coli develop renal failure after hysterectomy. In retrospective studies, kidney injuries were reported in a patient undergoing the surgical procedure, due to the diagnosis of pyometra as a primary disease, but there is no consensus about the levels of glomerular involvement. Currently, the diagnostic methods used, the concentration of serum urea and creatinine, are late and the significant elevations of these biochemicals are only identified when approximately 75% of the nephrons are already affected. Studies have shown that new markers, such as serum symmetric Dimethylarginine (SDMA) and the Urinary Glutamyl Transferase (uGGT) range, may be earlier in identifying renal injury than serum creatinine (sCr), the parameter routinely used. As well as the protein: urinary creatinine (uPC) ratio, which are important markers in the structural damage of the nephrons. Studies have shown an increase in SDMA by 25% reduction in glomerular filtration; uGGT can be identified in urine in lesions of tubular cells, since it is an enzyme present inside these cells. The UPC, although considered early in the harmful identification, does not determine the location of the renal insult. Anticipating the detection of kidney injury is essential for a quick adaptation of the treatment, avoiding severe and / or irreversible consequences, such as renal failure, and thus, allowing an increase in the treatment success rate.