00 CAMPUS ARISTÓTELES CALAZANS SIMÕES (CAMPUS A. C. SIMÕES) ICF - INSTITUTO DE CIÊNCIAS FARMACÊUTICAS TRABALHOS DE CONCLUSÃO DE CURSO (TCC) - GRADUAÇÃO - ICF Trabalhos de Conclusão de Curso (TCC) - Bacharelado - FARMÁCIA - ICF
Use este identificador para citar ou linkar para este item: http://www.repositorio.ufal.br/jspui/handle/123456789/16162
Tipo: Trabalho de Conclusão de Curso
Título: Anti-zika virus effects, placenta protection and chemical composition of passiflora edulis seeds ethanolic extract
Autor(es): Vila Nova, Monique Almeida
Primeiro Orientador: Borbely, Alexandre Urban
metadata.dc.contributor.referee1: Santos Júnior, Gerson Gomes dos
metadata.dc.contributor.referee2: Rodrigues, Mônica Meira Leite
Resumo: Various beneficial biological activities have been reported for passion fruit (Passiflora edulis), grown in tropical and subtropical regions. However, no study has yet demonstrated its action against the Zika virus (ZIKV) infection. The present study aimed to investigate the anti-ZIKV of the ethanolic passion fruit seed extract (PFSE), from which, liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis allowed to putatively annotate the occurrence of piceatannol, astringin, scirpusin A, scirpusin B, isookanin-7-O-glucoside and naringenin-7-O-glucoside, two quadranguloside derivatives, tyrosine, and phenylalanine. PFSE is well tolerated by cell lines (Vero E6 and HTR-8/SVneo) and tissue explants from the human placenta. With 1- and 24-h treatments, PFSE consistently reduced the viral load and NS1 protein expression of the two strains of ZIKV (MR766 and PE243) in placental explants and cell lines. Thus, PFSE has a promising potential for developing anti-ZIKV treatments, protecting the placenta against infection caused by ZIKV, along with relevant antioxidant potential, represented by ferric reducing antioxidant power (FRAP) of 390.5 Trolox eq per g dry extract and half maximal inhibitory concentration (IC50) for 2,2-diphenyl-1-picrylhydrazyl radical (DPPH•) of 12.1 µg mL–1, and more than 90% protection from lipid peroxidation. Although further studies need to be conducted, PFSE treatment was safe and effective in trophoblast cells and placental explants, thus representing a promising class of all-accessible products based on the reuse of industrial by-products.
Abstract: não tem
Palavras-chave: Passion fruit seeds
Placenta protection
Antiviral activity
Piceatannol
Agroindustrial waste
CNPq: CNPQ::CIENCIAS DA SAUDE::FARMACIA
Idioma: eng
País: Brasil
Editor: Universidade Federal de Alagoas
Sigla da Instituição: UFAL
metadata.dc.publisher.department: Curso de Fármacia - Bacharelado
Citação: VILA NOVA, Monique Almeida. Anti-zika virus effects, placenta protection and chemical composition of passiflora edulis seeds ethanolic extract. 2025. 16 f. Trabalho de Conclusão de Curso (Bacharelado em Farmácia) – Instituto de Ciências Farmacêuticas, Universidade Federal de Alagoas, Maceió, 2023.
Tipo de Acesso: Acesso Embargado
URI: http://www.repositorio.ufal.br/jspui/handle/123456789/16162
Data do documento: 1-ago-2023
Aparece nas coleções:Trabalhos de Conclusão de Curso (TCC) - Bacharelado - FARMÁCIA - ICF

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