00 CAMPUS ARISTÓTELES CALAZANS SIMÕES (CAMPUS A. C. SIMÕES) ICF - INSTITUTO DE CIÊNCIAS FARMACÊUTICAS TRABALHOS DE CONCLUSÃO DE CURSO (TCC) - GRADUAÇÃO - ICF Trabalhos de Conclusão de Curso (TCC) - Bacharelado - FARMÁCIA - ICF
Use este identificador para citar ou linkar para este item: http://www.repositorio.ufal.br/jspui/handle/123456789/16162
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dc.contributor.advisor1Borbely, Alexandre Urban-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/3999711350740879pt_BR
dc.contributor.referee1Santos Júnior, Gerson Gomes dos-
dc.contributor.referee2Rodrigues, Mônica Meira Leite-
dc.creatorVila Nova, Monique Almeida-
dc.date.accessioned2025-05-08T16:50:40Z-
dc.date.available2026-04-30-
dc.date.available2025-05-08T16:50:40Z-
dc.date.issued2023-08-01-
dc.identifier.citationVILA NOVA, Monique Almeida. Anti-zika virus effects, placenta protection and chemical composition of passiflora edulis seeds ethanolic extract. 2025. 16 f. Trabalho de Conclusão de Curso (Bacharelado em Farmácia) – Instituto de Ciências Farmacêuticas, Universidade Federal de Alagoas, Maceió, 2023.pt_BR
dc.identifier.urihttp://www.repositorio.ufal.br/jspui/handle/123456789/16162-
dc.description.abstractnão tempt_BR
dc.languageengpt_BR
dc.publisherUniversidade Federal de Alagoaspt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentCurso de Fármacia - Bachareladopt_BR
dc.publisher.initialsUFALpt_BR
dc.rightsAcesso Embargadopt_BR
dc.subjectPassion fruit seedspt_BR
dc.subjectPlacenta protectionpt_BR
dc.subjectAntiviral activitypt_BR
dc.subjectPiceatannolpt_BR
dc.subjectAgroindustrial wastept_BR
dc.subject.cnpqCNPQ::CIENCIAS DA SAUDE::FARMACIApt_BR
dc.titleAnti-zika virus effects, placenta protection and chemical composition of passiflora edulis seeds ethanolic extractpt_BR
dc.typeTrabalho de Conclusão de Cursopt_BR
dc.description.resumoVarious beneficial biological activities have been reported for passion fruit (Passiflora edulis), grown in tropical and subtropical regions. However, no study has yet demonstrated its action against the Zika virus (ZIKV) infection. The present study aimed to investigate the anti-ZIKV of the ethanolic passion fruit seed extract (PFSE), from which, liquid chromatography tandem mass spectrometry (LC-MS/MS) analysis allowed to putatively annotate the occurrence of piceatannol, astringin, scirpusin A, scirpusin B, isookanin-7-O-glucoside and naringenin-7-O-glucoside, two quadranguloside derivatives, tyrosine, and phenylalanine. PFSE is well tolerated by cell lines (Vero E6 and HTR-8/SVneo) and tissue explants from the human placenta. With 1- and 24-h treatments, PFSE consistently reduced the viral load and NS1 protein expression of the two strains of ZIKV (MR766 and PE243) in placental explants and cell lines. Thus, PFSE has a promising potential for developing anti-ZIKV treatments, protecting the placenta against infection caused by ZIKV, along with relevant antioxidant potential, represented by ferric reducing antioxidant power (FRAP) of 390.5 Trolox eq per g dry extract and half maximal inhibitory concentration (IC50) for 2,2-diphenyl-1-picrylhydrazyl radical (DPPH•) of 12.1 µg mL–1, and more than 90% protection from lipid peroxidation. Although further studies need to be conducted, PFSE treatment was safe and effective in trophoblast cells and placental explants, thus representing a promising class of all-accessible products based on the reuse of industrial by-products.pt_BR
Aparece nas coleções:Trabalhos de Conclusão de Curso (TCC) - Bacharelado - FARMÁCIA - ICF

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