Utilização de Imidazolatos Zeolíticos (ZIF-8) como sistemas de liberação de fármacos uma revisão de literatura

Abstract

ABSTRACT: OBJECTIVE. Carry out bibliographical research on the use of Zeolitic imidazolates (ZIF-8) as drug delivery systems. METHODOLOGY. A qualitative literature review was carried out, where selected articles were evaluated in the period between 2020 and 2023, through a bibliographic survey, using the Virtual Health Library (VHL) of the Ministry of Health as a database. The research was carried out using the descriptors: Drug Carriers, Metal-Organic Frameworks and Drug Delivery Systems in Portuguese, English and Spanish. RESULTS. As a result, 300 scientific articles were found, however, after applying the inclusion and exclusion criteria, 16 articles were selected. In general, most studies showed results of an improvement in bioavailability, encapsulation efficiency and targeted delivery of the drug, being the main class of chemotherapy drugs. CONCLUSION. In view of the above, it was noted that although the various innovations discovered have demonstrated efficient therapies, most of the studies are still in the in vitro or in vivo phase, with few studies in the clinical phase, requiring further advances for the its insertion into the market.