Ações do angiotensina-(1-7) em modelos dietéticos de estudo da síndrome metabólica em ratos: revisão sistemática e metanálise

Abstract

Metabolic syndrome (MetS) is a health problem and evidence has suggested that Angiotensin Ang- (1-7) may be a potential pharmacological approach to treat it. This systematic review aims to collect all available data on Ang- (1-7) in non-transgenic rats that used diets rich mainly in carbohydrates, to induce the risk factors for MS. The following electronic bibliographic databases were searched: PubMed, EMBASE, Web of Science and SCOPUS. The search strategy was based on the “animal models”, “metabolic syndrome” and “angiotensin- (1-7)” search components. No publication date or language restrictions were applied. Results: The protocol for this study is available online at PROSPERO. The research retrieved a total of 2100 citations (EMBASE, n = 837; PubMed, n = 2924; SCOPUS, n = 292; Web of Science, n = 677). All citations were saved to a file in the reference software. After removing duplicates (n = 891), a total of 1419 citations were screened based on the title and abstract, resulting in 149 citations selected as potentially relevant articles. Of these, 66 citations were summaries at conferences, leading to 83 citations to be assessed for eligibility, considering the content of the full text, after reading the studies in full, 13 articles were included for review. These 13 articles present considerable methodological differences, especially with regard to the intervention (dose, time of infusion and route of administration), as well as the diet used to induce the condition of MetS (duration, and type of diet: rich in Fructose and hyperlipidic diet). It was possible to perform a meta-analysis with 8 studies, 4 with a highfructose diet and 4 with a high-fat diet. The meta-analysis revealed an action favorable to the intervention with Ang- (1-7) on the glycemic profile, sensitivity to insulin and blood pressure. On the other hand, 12 studies failed to meet most of the quality parameters assessed, and 1 study presented a moderate risk of bias. Conclusion: This study suggests that, regardless of the route of administration, duration of the intervention and diet to induce MetS, the infusion of Ang- (1-7) consistently promoted the attenuation of the main risk factors present in MetS and that the most studies had a high risk of bias.