Efeitos da sinvastatina sobre a camada subendotelial arterial de coelhos albinos (Oryctolagus cuniculus) submetidos à dieta hiperlipídica

Abstract

Introduction: Atherosclerosis is a pathological condition which precedes the majority of cardiovascular events, named myocardial infarction and stroke. One of the most important factors involved in atherosclerosis is hyperlipidemia, a metabolic disorder that is presented by the elevation of plasma lipids, particularly cholesterol and triglycerides. The statins are used in endocrinology and cardiology for the treatment of dyslipidemia, its action is given by inhibiting the enzyme HMGCoA reductase. Therefore, it has become the objective of this study was to investigate the effects of sinvastatin on the structure of the thickening of the subendothelial layer in rabbits, as well as on the lipid profile; Methods: The rabbits were randomized into three groups, with n = 7, G1 (group control), G2 (treated with egg yolk) and G3 (yolk plus simvastatin). After 99 days of treatment the animals were killed under anesthesia and afterwards were dissected organs of interest removed from the blood and organs for histological processing; Results: Treatment with sinvastatin in hyperlipidemic rabbits subjected to diet for 99 days reduced 4.26% thickening of the arterial wall reduces plasma levels of total cholesterol at 31% and 59.7 and 75.1% of triglycerides, however, not reduce the fractions of LDL, VLDL and HDL models experimental administering exogenous cholesterol; Conclusion: Sinvastatin has a protective effect on the thickening of subendothelial and hypolipidemic effect.