Uso da fibrina rica em plaquetas na harmonização orofacial (HOF): revisão de literatura

Abstract

Introduction: Facial aging has led to a growing demand for minimally invasive aesthetic procedures that promote rejuvenation and enhance self-esteem. In this context, orofacial harmonization (OFH) has gained prominence, particularly with the use of Platelet-Rich Fibrin (PRF), an autologous biomaterial that supports tissue regeneration, healing, and controlled release of growth factors, providing natural and safe results. Objective: To analyze the existing literature on the use of Platelet-Rich Fibrin in orofacial harmonization, highlighting its relevance as a therapeutic resource in facial rejuvenation. Methods: A literature review was conducted using the SciELO, BVS, and PubMed databases with the descriptors “Platelet-Rich Fibrin,” “Orofacial Harmonization,” and “Tissue Engineering,” combined with the boolean operator AND. Articles published between 2015 and 2025, along with classical studies, were included. Results: The literature shows that PRF and its variations (L-PRF, A-PRF, i-PRF, APRF+, PRO-PRF) present promising results in improving skin quality, reducing wrinkles, and facial volumization, with low rates of complications. Conclusion: PRF is a safe and effective tool in OFH, with high regenerative and aesthetic potential, although it still requires protocol standardization and long-term clinical studies.