Frequência da síndrome metabólica e seu impacto sobre a qualidade de vida em pacientes com artrite reumatoide atendidos em um serviço de reumatologia de Alagoas

Abstract

Patients with rheumatoid arthritis (RA) have accelerated atherosclerosis, with a high risk of premature morbidity and mortality from cardiovascular disease (CVD), in addition to impaired quality of life (QoL). Metabolic syndrome (MetS), a set of factors associated with increased risk for CVD, has an increased frequency in these patients, contributing to the maintenance of a chronic inflammatory state. Therefore, the objective of this dissertation is to evaluate the frequency of MetS and its impact on QoL in patients with RA treated at a rheumatology unit in Alagoas. This is a case-control study that evaluated patients with RA in terms of demographic, clinical, laboratory and QoL data. The criterion used to define RA was that adopted by the American College of Rheumatology in collaboration with the European League Against Rheumatism (2010). For the diagnosis of MetS, the criteria defined by the Harmonized version (2009) were applied. To assess QoL, the Short Form 36 (1999) questionnaire was applied. A total of 71 patients were evaluated, of which 45 with RA (cases) and 26 controls (CT), being screened and ubdivided into 20 RA, 25 RA with MetS, 16 CT and 10 CT with MetS. The frequency of patients with MetS in the RA group was 54% (n = 45). Regarding QoL, it was observed that individuals with RA and MetS showed reater impairment of physical capacity and emotional status when compared with patients with RA and without MetS, and with CT patients with and without MetS. The results indicate that patients with RA have a high frequency of MetS and that this process may be associated with RA, as well as with targeted drug therapy. Another relevant point was QoL, as patients with RA and concomitant MetS had a greater QoL impairment when compared to other individuals.