Probióticos modulam a expressão de beta defesinas na periodontite apical induzida: estudo in vivo

Abstract

Probiotics are microorganisms that, when administered in adequate doses, confer health benefits for the host by modulating the immune-inflammatory response. Apical Periodontitis (AP) is a pathology that occurs in the alveolar bone causing an inflammatory reaction. As a consequence, cells secrete inflammatory cytokines and βdefensin 2 (hBD-2) and β-defensin 3 (hBD-3) are also expressed, which are antimicrobial peptides of the innate immune system. The aim of this study was to evaluate the expression of hBD-2 and hBD-3 after administration of a probiotic complex in rats with induced AP. PA was induced by pulp exposure and a probiotic complex from GNC (Lactobacillus acidophilus, Bifidobacterium bifidum, Bifidobacterim animalis subspecies lactis and Lactobacillus plantarum) was administered for 30 days. After euthanasia, histological sections were made to evaluate the expression of hBD2 and hBD-3 through immunohistochemistry. The levels of human β-defensin 2 (hBD2) and human β-defensin 3 (hBD-3) were significantly higher in the group that received the probiotic complex compared to the control group. (P<.05). Supplementation with probiotics had a significant effect on increasing the expression of human β-defensins -2 and -3 in induced apical periodontitis in rats.