Derivados benzimadazólicos, uma revisão: síntese, atividade biológica e potencial aplicação no controle do Aedes aegypti

Abstract

Benzimidazole is an important molecule from nitrogen heterocycles classes. This molecule and its derivatives shows important bioactives proprieties and are widely studied. Benzimidazoles are found in biological activities and therapeutics compounds, in natural products and as important intermediate in several organic reactions. Currently, the synthetic methods to form benzimidazoles derivatives searches for efficiency, good yelds, short reaction time, use of low cost reagentes that is environmental friendly, solvent free, etc. The biological activities from benzimidazole derivatives offers panoramic views about their importance to the pharmacological field, by presenting anticancer activity, as well antibacterian, fungicide, and others. Therefore, this work proposes a brief review about the current synthetic methods for obtaining benzimidazoles derivatives. As well as exemplify the versatility of biological activities from those derivatives and present these compounds as potent larvicidal agents for Aedes aegypti control.