Desenvolvimento de membrana polimérica enriquecida com própolis vermelha para auxílio no tratamento lesões por pressão

Abstract

Pressure Injuries (LPPs) are wounds on the skin and underlying tissue resulting from prolonged pressure combined with shear. Alagoas Red Propolis (PVA) is a natural product with clinically proven pharmacological activities, with its main biologically active components being phenolic compounds and flavonoids. Polymeric dressings possess controlled drug release capabilities and are used in wound treatments. The primary objective of this research was to develop a polymeric membrane enriched with PVA for the treatment of LPPs. Four membrane formulations were developed: MA-PV, MA-White, MG-PV, and MG-White. The lack of flexibility, brittle texture, and dry conformation of MA-PV led to the selection of MG-PV as the most suitable formulation for testing. During the research, the chemical composition of red propolis was analyzed by determining the total phenolic content of the EHPV extract using the Folin-Ciocalteu method and the total flavonoid content using the aluminum chloride method, yielding results consistent with literature findings. UV-Vis spectrum scanning indicated that the extraction system was suitable for recovering these metabolites from the matrix under study. Additionally, antioxidant activity was confirmed using the DPPH method, which demonstrated a percentage of radical inhibition, indicating enhanced antioxidant activity. Differential scanning calorimetry showed the phase transition processes of the membranes and their components; the MG-ARP membrane efficiently released the EHPV extract. In conclusion, it was demonstrated that EHPV extract can be incorporated into polymeric membranes, providing antioxidant activity and other biological properties. This EHPV-associated membrane could aid in wound treatment by accelerating the healing process.