Associação entre risco de suicídio e níveis plasmáticos de interleucina-6 em mulheres com lúpus eritematoso sistêmico

Abstract

Objective: To investigate the risk of suicide in patients with Systemic Lupus Erythematosus (SLE) and its association with plasma levels of Interleukin-6 (IL-6). Methods: Cross-sectional study, convenience sample of 53 women diagnosed with SLE and treated at the University Hospital of the Federal University of Alagoas. Data were collected through assessment instruments: sociodemographic questionnaire, MINI v.5.0.0, Beck Depression Inventory, Pittsburgh Sleep Quality Index, Short-Form-36 Form and peripheral blood collection for IL- 6 by ELISA. Results: The risk of suicide was present in 22.6% of the sample, and in 5.7% of the patients were severe risk. PSQI scores were 10.9 (±4.7) and 9.2 (±4.6) in the groups with and without suicide risk, respectively. There was an association between the risk of suicide and the presence of some psychiatric disorders, such as: agoraphobia (p<0.05), social anxiety disorder (p<0.05), OCD (p<0.05), bulimia (p<0.05), current psychosis (p<0.05) and depressive episode (p<0.05). Quality of sleep measured with PSQI indicated impairment in both groups but the difference between them was not significant (p=0,27). The IL-6 measurement means differed significantly in the presence of some mental disorders, such as: depression (p<0.05), bipolar disorder (p<0.05), lifetime psychosis (p<0.01 ), lifetime panic (p<0.05) and social phobia (p<0.05), but not with suicidal behavior (p=0.72). Conclusion: Suicide risk is highly prevalent among SLE patients and, is associated with current depression and anxiety disorders. Impairment in sleep quality and IL-6 scores did not differ between the groups with or without suicide risk.