Prevalência dos polimorfismos eNOS, IGFBP3 e TCF7L2 e sua associação com hipertensão arterial sistêmica: um estudo de base populacional com mulheres brasileiras descendentes de escravos africanos

Abstract

Individuals of African descent have higher prevalence of arterial hypertension, which seems to be related, among other factors, to genetic predisposition, however, this population is underrepresented in genetic studies. Thus, this thesis aimed to investigate the prevalence of NOS3 polymorphisms rs1799983, IGFBP3, rs11977526 and TCF7L2, rs7903146 in women of African descent from a state of Alagoas and their activities with arterial hypertension. A cross-sectional study was carried out with a probabilistic sample of 1021 women, aged 20 to 49 years, living in the quilombola community in the state of Alagoas. The present study evidences that the polymorphic variants NOS3 rs1799983, IGFBP3, rs11977526 are associated with higher blood pressure levels in Afro-descendant populations, consequently, with a higher prevalence of arterial hypertension. Afrodescendant Alagoas women with the TT genotype for the NOS3 gene and AA genotype for the IGFBP3 gene are more susceptible to arterial hypertension. These findings highlight the need to study groups of African descent to identify biological factors that contribute to hypertension.