Efeito agudo da suplementação de aminoácidos e cetoanálogos sobre a amonemia, enzimas biomarcadoras de dano muscular e contagem de células brancas em ciclistas submetidos a exercício físico com baixo estresse ao calor

Abstract

Ammonia is a toxic metabolite, and exercise-induced hyperammonemia associated with low carbohydratesdiet, results in deleterious effects in Central Nervous System and Peripheral causing possible damage to health and performance. Furthermore, the thermal stress seems to contribute to the increase in blood ammonia during exercise,in addition to increasing the production of reactive oxygen species, influencing the formation of enzymes biomarkers of muscle damage and immune system. Thus, resources that can alleviate high blood ammonia concentrations should be used to obtain benefits to athletic performance. The aim of the study was to verify the effect acute of keto analogues and amino acidsupplementation(KAAA) on blood ammonia, enzymes biomarkers of muscle damage and white blood cell count in cyclists during high intensity exercise under low heat stress environment. This study is composed of an introduction and two original articles. The first article "keto analogue and amino acid supplementation affects the enzymes biomarkers of muscle damage response during high intensity exercise under low heat stress environment" evaluated the effect of acute supplementation of KAAA in ammonia metabolism and enzymes biomarkers of damage muscle after high-intensity exercise under low heat stress environment. It has been demonstrated that acute supplementation was able of reducing blood ammonia concentrations and consequently enzymes biomarkers of muscle damage. The second article "keto analogue and amino acid supplementation affects white blood cells counts during high intensity exercise under low heat stress environment" evaluated the effect of acute supplementation of KAAA in total and differential content white blood cells after high-intensity exercise under low heat stress environment. It was demonstrated that supplementation attenuated some characteristic parameters of immunosuppression in white blood cells.