Efeitos neuroprotetor da lectina exógena galectina-1 no Status Epilepticus

Abstract

Intrahippocampal pilocarpine microinjection (H-PILO) induces Status Epilepticus (SE) that can lead to spontaneous recurrent seizures (SRS) and neurodegeneration in rodents. Studies using animal models have advanced knowledge of how lectins mediate a variety of biological activities with neuronal benefits, especially galectin-1 (Gal-1) that has been tentatively identified as an effective neuroprotective compound. Here, we administrated galectin-1 (Gal- 1) to Wistar rats and evaluated the severity of the SE, incidence of SRS and neurodegenerative patterns in the hippocampal region. We observed a reduction in inflammation and neurodegeneration 24 hours and 15 days after SE. However, there was na increase in neurodegeneration after 30 days of SE. Overall, our data suggest that the Gal-1 has neuroprotective effects in the early stage of epileptogenesis and provides new insights into the roles of exogenous lectins in temporal lobe epilepsy.