Inseto Tribolium castaneum como modelo experimental hiperglicêmico : nova estratégia de estudos

Abstract

Despite being a chronic condition, Diabetes Melittus is considered a pandemic, with a multifactorial cause and complex treatment, growing in terms of its incidence in the world, being a health problem but also an economic one, more and more in-depth studies are needed in relation to its risk factors, protective factors, and regarding the modernization of treatment, new options for study models useful in this condition are requested, the current models, mostly vertebrate, have several obstacles, methodological, budgetary or ethical, insects have been growing as alternative models that overcome many of these barriers; Thus, the objective of this work was to test the viability of the insect T. castaneum, the second most used insect as a model currently, as an option for studies of this purpose, for this sucrose was added to its diet, after supplementation, blood glucose parameters were observed , lipid profile and response to the drug of choice in DM: Metformin, the results show a possibility of using the insect as a viable model mainly for screening.