Manejo clínico-cirúrgico em pacientes portadores de deficiência do fator VII: uma revisão narrativa da literatura

Abstract

Introduction: Hereditary coagulopathies are bleeding disorders caused by deficiencies in coagulation factors, such as Factor VII, whose absence impairs thrombin and fibrin formation, increasing the risk of hemorrhage. In dentistry, surgical success and post-extraction healing are closely linked to hemostatic efficiency, which makes the clinical management of these patients critical. Objective: This study aimed to investigate, through a literature review, the clinical and surgical approaches used in patients with Factor VII deficiency. Methodology: The research was conducted using secondary data from databases such as PubMed, SciELO, and Google Scholar, using the following descriptors: Factor VII Deficiency; Factor VII; Surgery, Oral; Blood Coagulation. Results: The results emphasize the importance of understanding the molecular, clinical, and therapeutic aspects of the disorder to guide treatment. Conclusion: Recombinant activated Factor VII (rFVIIa) proved effective in preventing bleeding, especially when combined with local hemostatic agents. Although studies support the need for individualized planning, there is still a lack of standardized dental protocols for this patient population.