Efeitos de dieta cetogênica à base de óleo de coco ou de trienantina sobre o status epilepticus, induzido por injeção intraperitoneal de pilocarpina, em ratos

Abstract

Epilepsy is a chronic neurological disorder that affects people in all countries of the world, characterized by recurrent seizures, which are physical reactions to sudden and usually brief excessive electrical discharges in groups of cells located in different brain regions. Robust evidence to associate the table Status Epilepticus in childhood with the subsequent development of epilepsy. Status epilepticus is an acute state, characterized by a single prolonged epileptic seizures, with a duration greater than or equal to 30 minutes, or by repeating a shorter duration of seizures, without, however, the recobramento awareness of their ranges. Most people affected by epilepsy, when treated properly, achieves a satisfactory control of seizures. However, approximately 30% of affected individuals do not respond to drug therapy, the so-called anti-epileptic drugs, therefore, the indispensable necessity of affirming other therapeutic options, such as vagus nerve stimulation, ketogenic diet and surgery. This work highlights the importance of the ketogenic diet in the context of epilepsy farmacorresistente, a literature review, and verify the effect of different lipid sources in ketogenic ratios on the Status Epilepticus induced by pilocarpine in Wistar rats. Initially, the chapter is presented for review, entitled Ketogenic diet: control and prevention of epileptic seizures, which gathers information from the scientific literature about the use of the ketogenic diet rich in medium chain triglycerides, especially, like coconut oil and trienantin as an alternative nonpharmacological treatment for intractable epilepsy and for Status Epilepticus. Following an original article, entitled Effects of ketogenic diet based on coconut oil or trienantin on Status Epilepticus induced by intraperitoneal injection of pilocarpine in rats, which is an experimental study that investigated the impact of food intake ketogenic rich soy oil and medium chain triglycerides, based on coconut oil or trienantin in the prevention and / or control of epileptic seizures. The results obtained here allow us to assign a probable protective effect of ketogenic diets on the framework for Status Epilepticus presented by animals.