Análise metabolômica na identificação de alvos terapêuticos para esclerose lateral amiotrófica: uma revisão integrativa

Abstract

OBJECTIVE. To carry out a integrative review on the use of metabolomic analysis in identifying possible therapeutic targets for Amyotrophic Lateral Sclerosis (ALS). METHODOLOGY. A qualitative approach was adopted to identify relevant studies published between 2018 and 2023. The Virtual Health Library (VHL) of the Ministry of Health was used, using the descriptors: Amyotrophic Lateral Sclerosis, Metabolomics and Therapeutic Target in four languages (Portuguese, English, Spanish and French). RESULTS. After applying the filters, 16 articles were initially found, of which one was excluded after the exclusion criteria, resulting in 15 articles selected and analyzed. Most studies have shown promising results regarding the use of metabolomic analysis as a tool to identify effective therapeutic targets for ALS. CONCLUSION. Studies have highlighted changes in biomarkers and metabolic pathways important for the progression of ALS, contributing to the identification of complex mechanisms linked to the pathology. Metabolomic analysis identified changes capable of revealing predictive patterns for the evolution of the disease and, despite the need for validation, this approach emerges as an essential tool in the search for new therapeutic strategies.