Hidróxidos de terras raras lamelares e suas aplicações biotecnológicas uma revisão bibliográfica

Abstract

The present research explores the potential of layered rare-earth hydroxides (LRH) in biotechnological applications, emphasizing their unique properties, synthesis methods, and recent advancements in the field. These materials, characterized by a layered structure composed of rare-earth cations and intercalated anions, have proven valuable in areas requiring high ion-exchange capacity, thermal and chemical stability, and controlled substance release, as highlighted by Yapryntsev et al. (2020) and Huang et al. (2014). The systematic literature review sought to understand the gaps in the existing body of research and identify potential advancements in the application of LRH, including their advantages in controlled drug release processes and bioimaging, which are promising fields in biotechnology. A rigorous data collection was conducted in the Web of Science and Scopus databases, prioritizing recent, peer-reviewed articles directly addressing the properties and applications of LRH. The initial search resulted in 50 articles, of which 18 were excluded because they did not meet the inclusion criteria. After the complete analysis, 32 articles were selected to compose the whole review. Results indicate that while these hydroxides present great potential, challenges persist, especially regarding synthesis control and in-depth understanding of their interactions with bioactive compounds. Studies such as those by Hu et al. (2022) suggest that the molecule intercalation capacity and structural versatility of LRH enable their use in advanced medical diagnostics and efficient controlled drug release. In summary, this work deepens the understanding of LRH, emphasizing that continued research in this area is essential to overcome methodological challenges and enable large-scale applications.