Avaliação de marcadores inflamatórios em idosos renais crônicos com sobrepeso em fase não dialítica e suas implicações clínicas

Abstract

The present study aimed to evaluate the presence of overweight, associated with the profile of biochemical tests, inflammation markers and their clinical implications, in elderly patients with CKD. The study was carried out on an outpatient basis in a teaching hospital in Alagoas. Thirty patients of both sexes, aged over 60 years, with chronic kidney disease, were clinically and laboratory evaluated. After determining the BMI, the individuals were divided into eutrophic and overweight. The analyzes were performed using the Stata statistical package version 22.0. The mean age was 71.4 (±8.14) and BMI was in the overweight range, mostly sedentary, male and almost all of them had Systemic Arterial Hypertension. In the evaluation of renal function, the following laboratory markers were used: urea, creatinine and glomerular filtration rate. Regarding the inflammatory profile, the mean TNF-α was 807.51 (±47.24) for the eutrophic group and 808.57 (±60.20) for the overweight group, as well as the mean of IL-6 was 631.78 (±588.82) for the eutrophic group and 293.21 (± 258.66) being increased in both groups. Thus, the study showed that there were no significant differences in relation to cytokine values between the groups analyzed.