Associação entre nível de atividade física e preferência circadiana em pacientes com lúpus eritematoso sistêmico

Abstract

INTRODUCTION: Systemic lupus erithematosus (SLE) is an autoimmune condition of multisystem character associated with significant morbidity and mortality rates. Physical inactivity is highly prevalent in SLE. The phenotypic expression of an individual’s circadian rhythm or circadian preference is closely related to biological variables, and as a result it might influence the level of physical activity and clinical conditions in a population. OBJECTIVES: This study aimed verify level of physical activity and its associations with circadian preferences and clinical parameters in SLE. MATERIALS AND METHODS: 68 SLE patients according to ACR’s criteria for diagnosis were included in this research. Level of Physical activity and Circadian preference were assessed through Intenational Physcial Activty Questionare (IPAQ short form) and Horne and Ostberg Morningness – Eveningness Questionnaire (MEQ), respectively. Disease activity and organ damage were assessed through Systemic Lupus Erithematosus Disease Activity Index (modified SLEDAI-2K) and Systemic Lupus Internacional Collaborating Clinics/American College of Rheumatology-Damage (SLICC) Analyzed data were considered significant statically when p < 0,05. RESULTS: The patients were 57.4% classified as active, 26.5% irregular and 16.2% sedentary, according physical activity level. No statistically significance association between PA and chronotype was found, although the great majority of SLE patients whose were active had the morning and intermediate chronotype 95.6%. DISCUSSION Patients who practice easy physical activity: better physical function, pain and fatigue. The lowest levels of activity in the literature are those with a preference for an activity type that has an afternoon type, and the lowest activity levels with a greater number of activities (MVPA) in lower activity levels with a greater number of types (MVPA) at lower and intermediate times. On the other hand, a more robust sample is necessary for more conclusive results.