Diferença de alterações teciduais hepáticas em coelhos tratados com extrato alcoólico de Moringa oleifera em diferentes concentrações no controle da hiperplasia miointimal pós-angioplastia de ilíaca

Abstract

The liver is a crucial organ in the metabolism, and can metabolize many drugs, however it also may be damaged by them. Drug-induced hepatic lesions represent one of the most frequent cited reasons for the non-approval of drugs, their suspension, abandonment of use and also post-commercialization regulatory actions. The ethanolic extract of Moringa oleifera leaves has therapeutic effect in the reduction of the myointimal hyperplasia; however, the adverse effects of its use still need to be evaluated. Therefore, the objective of this study was to determine the difference of hepatic tissue alterations in rabbits treated with ethanolic extract of Moringa oleifera in different concentrations in the control of myointimal hyperplasia after iliac angioplasty. A five-week randomized clinical trial was carried out with experimental animals. The rabbits were divided into four groups, being thereby denominated: M400 (treated with ethanolic extract of M. oleifera leaves 400 mg/kg/day), M800 (treated with ethanolic extract of M. oleifera leaves 800 mg/kg/day), M1600 (treated with ethanolic extract of M. oleifera leaves 1600 mg/kg/day) and SS (treated with 0.9% saline solution mL/day). The histological evaluation of the liver showed normal architecture of the hepatic parenchyma in all the groups. With absence of leukocyte infiltrate in the lobes, in the portal space and central vein. There also was no alteration in the diameter and appearance of the central vein and portal space. There was significant statistical difference with regard to the hydropic degeneration in the liver between the groups M400 and M800 in relation to the negative control and between the group M800 in relation to the M1600. There was no statistically significant histological alteration in the kidneys.