Estudo da atividade antidiabética da polpa de camu-camu (Myrciaria dubia) em ratos diabéticos

Abstract

Diabetes mellitus is a group of metabolic diseases, characterized by chronic hyperglycemia caused by defects in the secretion and / or insulin action, is associated with complications, dysfunction and failure of various organs, leading to an increase in cost of control and treatment of disease. Traditional treatments cause side effects that lead to population and researchers look for natural alternatives for treating diabetes. Among these natural alternatives is the camu-camu (Myrciaria dubia), specimen included in Myrtaceae family and genus Myrciaria, native Amazon, which has a high content of ascorbic acid and flavonoids, in particular anthocyanins. Since there is no data in the literature on antidiabetic activity of the pulp of camucamu, coupled with the fact of the Myrtaceae family species possess indication for the treatment of diabetes, added to the proven biological activities of nutraceutical components that make up the plant, this thesis aims to investigate the effect of camucamu pulp in the treatment of diabetic rats induced, being developed in the form of two papers. At first, called “Camu-camu (Myrciaria dubia [Kunth] Mc Vaugh): A Review” presents a review of the species and its fruit with emphasis on nutritional and pharmacological studies on chemical constituents, antioxidant capacity and biological activity of Myrciaria dubia. The second article entitled "Effect of pulp Camu-Camu (Myrciaria dubia) in rats with diabetes induced by alloxan" refers to an experimental study using Wistar rats were divided into three groups: Control (normoglycemic), Salina (diabetic control) and Camu-camu (diabetics treated pulp of camu-camu, 3.0 ml / kg), treated for 28 days. Diabetes was induced by alloxan (42 mg / kg i.v.). Fasting glucose, glycated hemoglobin, lipid profile, alanine aminotransferase - ALT, aspartate aminotransferase - AST, urea and creatinine levels were evaluated. The animals treated with camu-camu pulp had significantly reduced glucose and LDL-cholesterol. These activities may be related to the presence of phenolic compounds in the pulp of camu-camu, and may be a fruit camucamu used as an aid in the treatment of diabetes.