Uso da fibrina rica em plaquetas na estética e rejuvenescimento facial: revisão integrativa

Abstract

Platelet-rich fibrin (PRF) is considered a filler biomaterial, currently used in both the medical and dental fields. This study aims to evaluate the use of PRF in aesthetic procedures and whether its use has a rejuvenating action on the face. The study uses the terms "Platelet-rich fibrin", "Facial rejuvenation", "Tissue engineering" and "Cosmetic dentistry" to refine the search in the databases: PUBMED, MEDLINE and LILACS, between the beginning of the year 2016 to March of 2021. The criteria for inclusion of the articles were the use of the PRF in case studies and clinical trials in the rejuvenation of the face. The exclusion criteria eliminated repeated studies, which adopted a different design from the aforementioned, or that addressed a therapy using the PRF that was not on the face. It was found with the search 6 experimental or observational studies considered eligible, which were included in the qualitative synthesis. The studies included showed that there is no standardization regarding the preparation of the PRF, with different protocols for the application of this biomaterial, and that although the authors have been successful and observed improvement in relation to the skin aspect, there is a “high” or “indefinite” risk bias favoring positive results. It was concluded that the PRF is a safe material and has resulted in the improvement of the skin's appearance, requiring future studies that analyze its long-term effect.