Fatores de risco associados ao aumento da peroxidação lipídica em pacientes com doença inflamatória intestinal

Abstract

Inflammatory Bowel Disease (IBD), which includes Crohn's Disease (CD) and Ulcerative Colitis (UC), is a chronic condition characterized by recurrent intestinal inflammation, associated with an imbalance in the redox system and increased oxidative stress. This study aimed to investigate the association between risk factors and lipid peroxidation, measured by malondialdehyde (MDA) levels, in patients with IBD. A cross-sectional study was conducted with 58 patients followed at the University Hospital Professor Alberto Antunes (HUPAA), where the sociodemographic, clinical, and behavioral profiles of the participants were evaluated. The results indicated that male gender and body weight are significantly associated with higher MDA levels, suggesting a greater predisposition to oxidative stress in these groups. Additionally, patients with CD had significantly higher MDA levels compared to those with UC, reflecting greater oxidative stress in CD. These findings highlight the importance of differentiated therapeutic approaches and personalized management strategies to improve the control of oxidative stress and, consequently, the progression of IBD. It is concluded that interventions focused on weight control and the use of antioxidant therapies may be promising in the management of patients with IBD, particularly in Crohn's Disease.