Toxicidade relacionada ao uso dos medicamentos do "Kit Covid': uma revisão narrativa da literatura

Abstract

In 2019, in the Chinese city of Wuhan, a group of patients was diagnosed with pneumonia whose cause was unknown, caused by a new virus that had not previously been detected in humans, later identified as severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2), which causes the Covid-19 disease, which manifests itself through symptoms: fever, dry cough, difficulty breathing, headache and pneumonia, which can lead to progressive respiratory failure due to alveolar damage and death. Since the beginning of the new pandemic, there has been a constant search for drugs for the prophylaxis and treatment of Covid-19, several drugs have been used off-label, that is, for purposes not described in the package insert, based on reports of activity against the virus in in vitro study or human studies with major methodological limitations. In this way, this work has the primary objective of exposing the main adverse reactions of the base drugs that make up the covid kit through a narrative review of the literature, without relating the drugs discussed here to the existence or not of effectiveness in the treatment of Covid-19. , even with the existence of scientific evidence regarding the ineffectiveness of this kit, both for treatment and prevention. It is concluded that in the current context, the questions of these reactions emerge as a theme that deserves attention, as it involves health, development and economy. Thus, it is expected that the present work can add to the debate and contribute to the discussion regarding the use of these drugs as a pharmacological therapy for Covid-19 and contribute to the consolidation of the importance of considering the adverse reactions of these drugs and the health risks of the patient.