Sarcopenia em doenças autoimunes: uma revisão sistemática e meta-análise

Abstract

Autoimmune diseases (ADs) involve a heterogeneous group of diseases that can compromise multiple organs. It is supposed that some immune dysregulation can reorient energy expenditure and favor a lack of reserves that alter metabolism. In this context, muscle response may follow different patterns, resulting in the development of sarcopenia. This is defined as ―a generalized and progressive skeletal muscle disorder‖, which uses the detection of low muscle strength as the primary diagnostic criterion. Aiming to contribute to the discussion of the problem, this dissertation presents a literature review, which recovers the main ones affect the relationship of sarcopenia in ADs, and an original article based on a systematic review and meta-analysis that aimed to systematically review the available findings. on the prevalence of sarcopenia in patients with ADs, estimated prevalence of the included studies, as well as evaluating as substantial sources of heterogeneity. Systematic searches in databases were performed. To identify sarcopenia, the diagnostic criteria recommended by scientific societies were considered, as well as the criteria developed by the authors of the studies, provided they are justified and based on the existing literature. After each screening step of article selection, the prevalence of sarcopenia in AD was estimated. From the results found in this review and meta-analysis, it is confirmed that such an approach is necessary in response to the high rates of morbidity and mortality that both disorders provide, in order to contribute to better clinical and therapeutic outcomes for these patients.