Uso de nanopartículas como sistema de liberação de fármacos utilizados no tratamento da leishmaniose

Abstract

To conduct a literature review on the application of nanoparticles as drug delivery systems in the therapy of leishmaniasis. A literature review was carried out by consulting bibliographic data available in the Virtual Health Library (VHL) of the Ministry of Health. The descriptors were used: Nanoparticles OR Nanoparticles OR Nanoparticles; AND "Nanoparticle Drug Release Systems" OR "Nanoparticle Drug Administration System" OR "Nanoparticle Drug Delivery System"; AND Leishmaniasis OR Leishmaniasis OR Leishmaniasis; and the filters: full text, english and period from 2019 to 2024. After obtaining the articles, inclusion/exclusion criteria were applied. RESULTS: As a result, 75 scientific articles were found; however, by applying the inclusion and exclusion 323 criteria, only 11 articles were selected. Of these, the use of nanoparticles associated with oral, topical and photodynamic drugs was evaluated. It was observed that the use of nanoparticles in anti-leishmanial therapies is an area on the rise, contributing to the minimization of adverse effects associated with medications, in addition to enhancing effectiveness in the treatment of leishmaniasis.