Modelagem computacional para recomendação de parâmetros de dispositivos de assistência ventricular pulsáteis por meio da análise da resposta cardiovascular

Abstract

Cardiovascular diseases significantly impact global mortality rates. In cases of heightened severity, using ventricular assist devices (VADs) provides a vital conduit for patients, thereby extending life expectancy. This article employs a coupled lumped parameter model (0D-model) of the human cardiovascular system (HCS) with a 0d-model of a pulsatile VAD (PVAD). The primary objective of this research is to recommend PVAD parameters to enhance patients’ physiological responses. While the existing academic literature pertains solely to methodologies applied to rotational VADs, a substantial gap exists in applying these methodologies to pulsatile devices. The recommendation aims to determine the ideal combination of two device parameters: the ejection pressure (Pe) and the ejection instant (δP V AD) between two consecutive heartbeats. Confidence intervals for a specific set of hemodynamic variables were obtained from the literature. An objective function assessed whether all hemodynamic variables remain within the specified confidence intervals for a given combination of Pe and δPVAD. Results demonstrate the feasibility of determining an ideal combination of Pe and δPVAD for the operating mode of the PVAD concerning a specific set of hemodynamic variables.