O uso não racional de anti-histamínicos H1 e efeitos toxicológicos em crianças: revisão sistemática

Abstract

In Brazil, the main agents causing poisoning in 2017 were medications, responsible for 27.11% of cases, of which the most affected age group were children aged 1 to 4 years old. Popularly administered to children, first-generation antihistamines, which interact with H1 receptors, cause several toxic effects, mainly on the CNS, and can cause extreme drowsiness, mental confusion, delirium, respiratory depression, hypothermia and even death. Overexposure to these medications in the first years of life may contribute to the exacerbation of symptoms related to some psychosocial disorders, such as anxiety and Attention Deficit Hyperactivity Disorder (ADHD) symptoms.