Hiperferritinemia piora desfechos perinatais em conceptos de gestações com pré-eclâmpsia

Abstract

Pre-eclampsia is one of the major causes of maternal morbidity and mortality, especially in developing countries. Risk factors and complications are described in the literature, but its pathophysiology has not been fully elucidated. Inflammation has been described as a key role and inflammatory biomarkers have been analyzed and associated with this disease. Considering that inflammation also implies fetal development, this study aimed to analyze the prevalence of hyperferritinemia in pregnant women with preeclampsia and its association with adverse perinatal outcomes. Thus, the present dissertation is composed of two chapters, one referring to the literature review that based the ferritin as an inflammatory marker and the other one corresponding to a cross-sectional study performed in a reference maternity for high risk gestation in the state of Alagoas, in the year of 2017, based on the objective of this study, being that 206 pregnant women with preeclampsia and their newborns were studied and the results analyzed by means of Poisson regression, with p <0.05 as significant. Finally, hyperferritinemia was associated with preeclampsia and a increase in the occurrence of adverse perinatal outcomes, such as low birth weight and low birth length, birth of a small newborn to gestational age, and intercurrences at birth. Studies such as this are important in the monitoring and identification of markers that can be used in prediction and as decision aids that reduce or attenuate the complications of the disease.