Estudo do comportamento metabólico e do efeito do treinamento físico aeróbio em ratos com depressão induzida por estresse crônico

Abstract

Increased life expectancy of the world population has grown enough with the progress of scientific research in last decades. In turn, the increase in life expectancy is directly related to the largest number of cases of chronic degenerative diseases such as mood disorders. Among mood disorders, depression deserves special mention. Research has demonstrated the role of aerobic exercise, done regularly, in the prevention and treatment of some diseases such as cardiovascular disease, metabolic syndrome, diabetes, obesity and anxiety. This dissertation aims to analyze the metabolic behavior of trained rats and subjected to depression, which were divided into two parts. The first, is called a literature review The neurobiology of depressive disorders, which presents data essential to the conceptual study of depression in relation to the signs and symptoms, factors that predispose the disease, central and peripheral areas with altered physiological activity, some cases of depression and stress as a factor that increases an individual's risk of developing it. The second part consists of the article, entitled Metabolic Behavior of Rats Trained and Depression Induced by Chronic Stress, discusses the experimental study performed in male Wistar rats, which were established 4 experimental groups, designated as CS (Control Sedentary, n = 7), CT (Trained Control, n = 6), CMS-S (Stressed Sedentary, n = 9) and CMS-T (Trained Stressed, n = 8). The experimental period lasted 8 weeks, where they were evaluated anhedonia, body weight, food intake and efficiency, anaerobic threshold and body temperature. There was significant reduction in consumption of sucrose solution in the second week of experiment in group CMS-S, while aerobic exercise prevented the onset of anhedonia in group CMS-T. In the analysis of feed efficiency of stressed animals were detected higher values at the end of the study. Was also detected a greater variation of body temperature of trained animals. Thus, it is suggested that exercise training prevented in stressed animals, the framework of anhedonia, a major clinical signs of depression.