Síntese e caracterização de cerâmicas bifásicas de fosfato de cálcio (Hap - ß-TCP) puras e dopadas com magnésio

Abstract

The calcium phosphates have been extensively studied for biomedical applications due to their chemical and structural similarities with our mineral phase of teeth and bones. In this work, biphasic calcium phosphate ceramics - BCP (mixture of hydroxyapatite and β-tricalcium phosphate, Hap/β-TCP) pure and doped with magnesium were obtained by solid state reaction. Magnesium (Mg) is known as an important element in the composition of bones and teeth. Recent research has shown that the addition of Mg in BCP structure improves consists mainly in bone metabolism and mechanical properties, without affecting its biocompatibility. The samples were prepared by solid-state reaction, using calcium carbonate, monobasic ammonium phosphate and magnesium nitratehexahydrate, as precursorssource of calcium, phosphate and magnesium, respectively. For pure BCP samples,it was investigated the influence of heat treatment on the formation of the material and for samples doped with magnesium,it investigated the different doping levels in the BCP structure. Several characterization techniques were used. The composition of the crystalline phase and morphology of the prepared materials were characterized by X-ray Diffraction and Electron Scanning Microscopy, respectively. The functional groups were analyzed using Fourier Transform Infrared Spectroscopy and Raman Spectroscopy. Cytotoxicity tests were carried out and the results suggested that the materials prepared in this work have for biological application as biomaterials.