Estudo Fitoquímico e Avaliação Antinociceptiva e Anti-inflamatória de Erythrina mulungu (Fabaceae).

Abstract

Fabaceae family is one of the largest botanical families and of wide geographic distribution. Erythrina genus is among the several genus of this family. Erythrina mulungu, popularly known as mulungu, is a native tree of the southeast and northeast of Brazil. In the herbal medicine is considered an excellent sedative to treat anxiety, nervous coughs, agitation psicomotory and insomnia, besides asthma, bronchitis, hepatitis, gengivite, hepatic and esplenics inflammations and fevers. This work had as aim accomplishes the phytochemical investigation of the crude ethanolic extract of the root of E. mulungu, and the pharmacological evaluation of the ethanolic extracts of the root bark, root, stem bark and stem. As result, it has been isolated two substances of the root of E. mulungu, that were identified by infrared, 1H and 13C NMR analyses as Quercitrin and Luteollin, obtained from the chloroformic and Ethyl Acetate phases, respectively. These substances had never been isolated before from this species. All of the tested crude extracts, as well as the chloroformic and ethyl acetate phases of the root exhibited a significantly inhibition of the contortions induced by acetic acid. In the hot plate test, any extract and/or phase presented antinociceptive effect, indicating that the tested extracts and phases don t have central analgesic action. In the first phase of the formalin test, no sample presented significant statistic effect, and in the second phase, all of the extracts and phases induced reduction of the time of latency. In the peritonitis test all of the extracts and the chloroformic phase reduced the number of cells significantly in the peritoneal washed. Finally, we can conclude that the two identified substances are valuable for literature, once this is the first time they were isolated of this species; and the pharmacological tests were showed promising antiinflammatory potential for Erythrina mulungu.