Análise bioinformática das células de schwann na progressão do câncer de pulmão

Abstract

The phenomenon of carcinogenesis is a complex process that occurs through multiple genetic events that alter the normal functions of oncogenes and tumor suppressor genes. Studies have shown that Schwann cells participate in the tumor microenvironment, producing several factors that benefit câncer cells. During this process, Schwann cells are dedifferentiated and help the process of cancer cell proliferation. These cells then migrate to the region close to the tumor tissue and assist the development of the neoplastic cell. In this context, the aim of the present study was to evaluate the influence of Schwann cells over lung cancers. We performed a bioinformatic insights and we observed that the "neuroactive ligand-receptor interaction" pathway was upregulated in LUSC and downregulated in LUAD. The "p53 signaling pathway" was active in both lung cancers, since CCNE1, CDKN2A, and PERP were upregulated. Meanwhile, upregulated miRNAs inactivate the "axon guidance" pathway, targeting ROBO2 and SLIT2 genes. Both genes are also associated with Schwann cells migration inhibition. Also, GFAP and GAP43 are overexpressed, leading to Schwann cells dedifferentiation. Besides, both Schwann and cancer cells are stimulated via phosphorylation cascade to proliferate and migrate. We also believe that Schwann cells' dedifferentiation and proliferation are induced by neoplastic tissue; Consequently, Schwann cells produce different factors that Will participate in various processes of tumor progression. These processes may also be involved in tumor invasion into the perineural tissue, especially in LUSC.